Santee
- County:
- Orangeburg County
- County Seat:
- No
- Area (mi²):
- 2.501
- State:
- South Carolina
Santee is a town located in Orangeburg County, South Carolina. Santee has a 2026 population of 814. Santee is currently declining at a rate of 0% annually and its population has decreased by -1.93% since the most recent census, which recorded a population of 830 in 2020.
The median household income in Santee is $46,667 with a poverty rate of 28.27%. The median age in Santee is 47.4 years: 40.1 years for males, and 56.2 years for females. For every 100 females there are 100.0 males.