Mayesville
- County:
- Sumter County
- County Seat:
- No
- Area (mi²):
- 1.024
- State:
- South Carolina
Mayesville is a town located in Sumter County, South Carolina. Mayesville has a 2026 population of 550. Mayesville is currently growing at a rate of 0.55% annually but its population has decreased by -0.36% since the most recent census, which recorded a population of 552 in 2020.
The median household income in Mayesville is $50,568 with a poverty rate of 29.93%. The median age in Mayesville is 36.2 years: 36.5 years for males, and 36.1 years for females. For every 100 females there are 74.8 males.