De Kalb
- County:
- Buchanan County
- County Seat:
- No
- Area (mi²):
- 0.255
- State:
- Missouri
De Kalb is a town located in Buchanan County, Missouri. De Kalb has a 2026 population of 239. De Kalb is currently growing at a rate of 1.7% annually and its population has increased by 3.91% since the most recent census, which recorded a population of 230 in 2020.
The median household income in De Kalb is $94,028 with a poverty rate of 7.72%. The median age in De Kalb is 28.1 years: 25.4 years for males, and 36.1 years for females. For every 100 females there are 93.3 males.