Mayersville
- County:
- Issaquena County
- County Seat:
- Yes
- Area (mi²):
- 1.101
- State:
- Mississippi
Mayersville is a town located in Issaquena County, Mississippi. Mayersville has a 2026 population of 464. It is also the county seat of Issaquena County. Mayersville is currently growing at a rate of 5.94% annually and its population has increased by 7.66% since the most recent census, which recorded a population of 431 in 2020.
The median household income in Mayersville is $15,179 with a poverty rate of 30.1%. The median age in Mayersville is 43.5 years: 48 years for males, and 42.4 years for females. For every 100 females there are 78.2 males.