Ponce de Leon
- County:
- Holmes County
- County Seat:
- No
- Area (mi²):
- 4.961
- State:
- Florida
Ponce de Leon is a town located in Holmes County, Florida. Ponce de Leon has a 2026 population of 518. Ponce de Leon is currently growing at a rate of 0.39% annually and its population has increased by 3.39% since the most recent census, which recorded a population of 501 in 2020.
The median household income in Ponce de Leon is $77,798 with a poverty rate of 11.92%. The median age in Ponce de Leon is 28.7 years: 25.7 years for males, and 46.5 years for females. For every 100 females there are 111.4 males.